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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SOS2
All Species:
30.91
Human Site:
S185
Identified Species:
68
UniProt:
Q07890
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q07890
NP_008870.2
1332
152979
S185
Q
D
D
I
G
L
V
S
L
C
E
D
E
P
S
Chimpanzee
Pan troglodytes
XP_515425
1598
179688
S452
V
E
D
I
N
I
L
S
L
T
D
E
E
P
S
Rhesus Macaque
Macaca mulatta
XP_001099864
1331
152695
S185
Q
D
D
I
G
L
V
S
L
C
E
D
E
P
S
Dog
Lupus familis
XP_547804
1363
156214
C216
Q
D
D
I
G
L
V
C
L
C
E
D
E
P
S
Cat
Felis silvestris
Mouse
Mus musculus
Q02384
1333
153108
S186
D
D
D
I
G
L
V
S
L
C
E
D
E
P
C
Rat
Rattus norvegicus
NP_001129033
1333
153157
S186
D
D
D
I
G
L
V
S
L
C
E
E
E
P
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515100
1332
152934
S185
Q
D
D
I
G
L
V
S
L
C
E
D
E
P
S
Chicken
Gallus gallus
XP_421461
1466
167231
S321
Q
D
D
I
G
L
V
S
L
C
E
D
E
P
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_690171
1343
153249
S182
E
E
E
M
G
L
L
S
Q
S
V
E
E
V
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P26675
1596
177916
P235
Q
S
E
A
H
I
L
P
S
P
L
S
L
P
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782335
1310
150821
S185
A
T
A
M
S
S
L
S
L
E
D
E
Q
D
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58.7
99
93.2
N.A.
94.9
94.6
N.A.
91.1
78.9
N.A.
73
N.A.
39.8
N.A.
N.A.
52.1
Protein Similarity:
100
68.5
99.7
95.5
N.A.
97.9
97.4
N.A.
95.9
84.7
N.A.
83.9
N.A.
55.1
N.A.
N.A.
68
P-Site Identity:
100
46.6
100
93.3
N.A.
86.6
80
N.A.
100
100
N.A.
33.3
N.A.
13.3
N.A.
N.A.
20
P-Site Similarity:
100
80
100
93.3
N.A.
86.6
86.6
N.A.
100
100
N.A.
73.3
N.A.
40
N.A.
N.A.
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
10
10
0
0
0
0
0
0
0
0
0
0
10
% A
% Cys:
0
0
0
0
0
0
0
10
0
64
0
0
0
0
19
% C
% Asp:
19
64
73
0
0
0
0
0
0
0
19
55
0
10
0
% D
% Glu:
10
19
19
0
0
0
0
0
0
10
64
37
82
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
73
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
73
0
19
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
73
37
0
82
0
10
0
10
0
0
% L
% Met:
0
0
0
19
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
10
0
10
0
0
0
82
0
% P
% Gln:
55
0
0
0
0
0
0
0
10
0
0
0
10
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
10
0
0
10
10
0
82
10
10
0
10
0
0
73
% S
% Thr:
0
10
0
0
0
0
0
0
0
10
0
0
0
0
0
% T
% Val:
10
0
0
0
0
0
64
0
0
0
10
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _